Synthesis and biological activity of (MeTyr1,MeArg7,D-Leu8)-dynorphin A(1-9)-NHEt and (D-Cys2-Cys5,MeArg7,D-Leu8)-dynorphin A(1-9)-NH2.
نویسندگان
چکیده
منابع مشابه
Absence of -9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice
The involvement of dynorphin on -9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chron...
متن کاملsynthesis and characterization of potentially biological active cyclometallated organoplatinum(ii) complexes
this work is presented in five parts. in the first part preparation of the starting complex [pt(c^n)cl(dmso)], 1, in which c^n = n(1),c(2?)-chelated, deprotonated 2-phenylpyridine, and dmso = dimethylsulfoxide, and its reaction with 1 equiv of the biphosphine ligands bis(diphenylphosphino)amine, dppa, or bis(diphenylphosphino)methane, dppm, to give the complex [pt(c^n)cl(dppa)], 2, or [pt(c^n)c...
15 صفحه اولNew oleandomycin 9-oximes. Synthesis, characterization and biological activity.
A series of the novel oleandomycin 9-oximes has been prepared and characterized by spectroscopic data and X-ray analysis. The antibacterial in vitro activities of the oximes (6-10) were compared with that of oleandomycin (1). Among the novel derivatives the most active compound was 8(R)-methyloleandomycin-9-oxime (9) in contrast ot its 8(S)-isomer (10) which possessed only low potency. Some pre...
متن کامل[ D - Ala 2 , ( Fs ) Phe 4 ] - Dynorphin 1 - - 13 - N H 2 ( DAFPHEDYN ) : A Potent Analog of Dynorphin 1 - 13
WALKER, J. M., D. H. COY, E. A. YOUNG, G. BALDRIGHI, S. F. SIEGEL, W. D. BOWEN AND H. AKIL. [D-AIa z, (F~)Phe4]-Dynorphin~_la-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13. PEPTIDES 8(5) 811-817, 1987.-Intracerebroventricular administration of the dynorphin analog, [D-Ala2,(Fs)Phe4]-dynorphint_l~-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonize...
متن کاملsynthesis of sulfides from alcohols and thiols in solvent-freeconditions and deoxygenation of sulfoxides
کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1990
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.38.2274